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cell.swf

This is the info page for
Flash #234960

(Click the ID number above for more basic data on this flash file.)


Text
ß-cat

A
P
C

GSK3

GSK-3
phosphorylates
ß-catenin, APC,
and Axin

STOP

START

GBP

Dsh

WNT

click me
to see Wnt
signalling

TCF

Groucho

L
R
P

CtBP

Frizzled

Axin

GSK-3
Phosphorylates
ß-catenin

ß-catenin is
ubiquitinated and
broken down by
the proteosome

ß-cat

LEF/TCF transcription
factors, with co-
repressors, Groucho
and CtBP, repress
gene transcription

LEF/TCF transcription
factors, with co-
repressors Groucho
and CTBP, repress
gene transcription

click me
to stop Wnt
signalling

Wnt binds
Frizzled receptor

Dishevelled becomes
activated, likely
by phosphorylation

Dsh

Repression of GSK3
by Dsh involves GBP
action, and perhaps
dissociation of GSK3
from the complex

ß-catenin
accumulates

ß-catenin enters
nucleus, binds TCF
transcription factor
and activates
gene transcription

ActionScript [AS1/AS2]

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Frame 616
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Frame 632
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Frame 676
gotoAndPlay (1);
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on (release) { gotoAndStop (220); }
Symbol 104 Button
on (release) { gotoAndPlay (617); }
Symbol 130 Button
on (release) { gotoAndPlay (1); }
Symbol 131 Button
on (release) { gotoAndPlay (230); }

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Created: 9/5 -2020 14:35:19 Last modified: 9/5 -2020 14:35:19 Server time: 22/12 -2024 10:31:54